Organ & tissue-specific manifestation and Principles of treatment & prevention
Sanyam Jain, Academic Content Writer
Organ & tissue-specific manifestation of infectious diseases
Organ of disease manifestation
Target organ linked to point of entry–
Air-borne pathogen enters through nose and infects lungs e.g. TB
Microbe brought via food/water into mouth stay in gut e.g. typhoid
Target organ different from point of entry–
HIV enters through genitals but infects lymph nodes
Malarial parasite enters via mosquito bite goes to liver and then attacks RBCs
Brain fever virus enters through mosquito bite but infects brain
Symptoms linked to target organs (tissue-specific effects)
Breathlessness- lungs
Jaundice- liver
Headaches, vomiting, fits or unconsciousness- brain
Immune system linked responses (common effects)
Inflammation– recruitment of immune cells to affected site causing
Local effects such as swelling and pain
General effects such as fever
HIV-AIDS: special case
Tissue-specificity of infection produces general-seeming effects
Minor infections become fatal due to immune function loss
Examples: common cold becomes pneumonia, gut infection becomes major diarrhoea
Other infections kill people suffering from HIV-AIDS
Factors determining severity of disease manifestation
Number of pathogens in the body
Strength of immune system of the body
Toxicity of pathogens entering the body
Principles of treatment
Two ways to treat an infectious disease–
Reduce the effects of the disease
Symptom-directed treatment
Do not eliminate the disease
Provide relief to the body
Examples: taking medicines to bring down fever or reduce pain, bed-rest to conserve energy
Kill the cause of disease
Taking drugs that kill the pathogens (e.g. antibiotics)
Antiviral drugs are hard to make-
Viruses use the host cell machinery
Viruses have few biochemical mechanisms of their own
Three limitations of treatment-
Damage to bodily functions of patients
Loss of working days of patients
Patients act as a source of infections
Principles of prevention
“Prevention is better than cure’’
Two ways to prevent an infectious disease–
General for all diseases
No exposure to pathogens by maintaining public hygiene
Air-borne diseases- Avoid overcrowdedness
Vector-borne infections- Live in clean environments
Water-borne microbes- Provide safe drinking water
Strengthening immunity by taking proper and sufficient food
Specific to each disease
Principle of immunisation- re-exposure of pathogens to immune system results in its quick elimination
Immune system develops memory of infection
Vaccination– disease-specific means of prevention